Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age.

ABSTRACT: Organ function declines with age, and large-scale transcriptomic analyses have highlighted differential aging trajectories across tissues. The mechanism underlying shared and organ-selective functional changes across the lifespan, however, still remains poorly understood. Given the central role of mitochondria in powering cellular processes needed to maintain tissue health, we therefore undertook a systematic assessment of respiratory activity across 33 different tissues in young (2.5 months) and old (20 months) mice of both sexes. Our high-resolution mitochondrial respiration atlas reveals: 1) within any group of mice, mitochondrial activity varies widely across tissues, with the highest values consistently seen in heart, brown fat, and kidney; 2) biological sex is a significant but minor

SUBMITTER: Sarver DC 

PROVIDER: S-EPMC10996676 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature