Altered intrinsic ignition dynamics linked to Amyloid-<i>β</i> and tau pathology in Alzheimer's disease.

ABSTRACT: Alzheimer's disease (AD) progressively alters brain structure and function, yet the associated changes in large-scale brain network dynamics remain poorly understood. We applied the intrinsic ignition framework to resting-state functional MRI (rs-fMRI) data from AD patients, individuals with mild cognitive impairment (MCI), and cognitively healthy controls (HC) to elucidate how AD shapes intrinsic brain activity. We assessed node-metastability at the whole-brain level and in 7 canonical resting-state networks (RSNs). Our results revealed a progressive decline in dynamical complexity across the disease continuum. HC exhibited the highest node-metastability, whereas it was substantially reduced in MCI and AD patients. The cortical hierarchy of information processing was also disrupted, indic

SUBMITTER: Patow GA 

PROVIDER: S-EPMC10996678 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature