Carbon dioxide shapes parasite-host interactions in a human-infective nematode.

ABSTRACT: Skin-penetrating nematodes infect nearly one billion people worldwide. The developmentally arrested infective larvae (iL3s) seek out hosts, invade hosts via skin penetration, and resume development inside the host in a process called activation. Activated infective larvae (iL3as) traverse the host body, ending up as parasitic adults in the small intestine. Skin-penetrating nematodes respond to many chemosensory cues, but how chemosensation contributes to host seeking, intra-host development, and intra-host navigation - three crucial steps of the parasite-host interaction - remains poorly understood. Here, we investigate the role of carbon dioxide (CO₂) in promoting parasite-host interactions in the human-infective threadworm Strongyloides stercoralis. We show that S. s

SUBMITTER: Banerjee N 

PROVIDER: S-EPMC10996684 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature