An EEG Signature of MCH Neuron Activities Predicts Cocaine Seeking.

ABSTRACT:

Background

Identifying biomarkers that predict substance use disorder (SUD) propensity may better strategize anti-addiction treatment. The melanin-concentrating hormone (MCH) neurons in the lateral hypothalamus (LH) critically mediates interactions between sleep and substance use; however, their activities are largely obscured in surface electroencephalogram (EEG) measures, hindering the development of biomarkers.

Methods

Surface EEG signals and real-time Ca²⁺ activities of LH MCH neurons (Ca²⁺_MCH) were simultaneously recorded in male and female adult rats. Mathematical modeling and machine learning were then applied to predict Ca²⁺_MCH using EEG derivatives. The robustness of the predictions was tested across sex and tre

SUBMITTER: Wang Y 

PROVIDER: S-EPMC10996698 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature