Whole genome sequencing and transmission analysis of <i>Vibrio cholerae</i> isolates from Eastern and Southern Africa: a genomic epidemiology study.

ABSTRACT:

Background

Despite ongoing containment and vaccination efforts, cholera remains prevalent in many countries in sub-Saharan Africa. Part of the difficulty in containing cholera comes from our lack of understanding of how it circulates throughout the region, so this study uses genomic epidemiology to identify disease transmission patterns in Southern and Eastern Africa.

Methods

To better characterize regional transmission, we performed whole genome sequencing on 142 Vibrio cholerae samples of different sample types, each collected between 2007-2019 from five different countries in Southern and Eastern Africa. We obtained 114 high quality V. cholerae genomes that we combined with 1385 previously published genomes to conduct phylogenetic and other analyses used to

SUBMITTER: Xiao S 

PROVIDER: S-EPMC10996759 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature