Assessment of Time Lag Between Blood Flow, Retinal Nerve Fiber Layer Thickness and Visual Field Sensitivity Changes in Glaucoma.

ABSTRACT:

Purpose

This study investigates the temporal relationship between blood flow changes and alterations in retinal nerve fiber layer thickness (RNFLT) and mean deviation (MD) in individuals with glaucoma.

Methods

Blood flow, measured by mean blur rate in optic nerve head vessels (MBRv) and tissues (MBRt) using laser speckle flowgraphy (LSFG)-NAVI, was analyzed using structural equation models (SEMs). SEMs assessed whether the previous rate of one parameter predicted the current rate of the other parameter, adjusted for its own rate in the previous time interval. Data from 345 eyes of 174 participants were gathered from visits every six months.

Results

Rates of change of both MBRv and MBRt were significantly predicted by their own rate in the previous time interval and by

SUBMITTER: Higgins BE 

PROVIDER: S-EPMC10996942 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature