Pan-cancer and single-cell analysis of actin cytoskeleton genes related to disulfidptosis.

ABSTRACT: Disulfidptosis was recently reported to be caused by abnormal disulfide accumulation in cells with high SLC7A11 levels subjected to glucose starvation, suggesting that targeting disulfidptosis was a potential strategy for cancer treatment. We analyzed the relationships between gene expression and mutations and prognoses of patients. In addition, the correlation between gene expression and immune cell infiltration was explored. The potential regulatory mechanisms of these genes were assessed by investigating their related signaling pathways involved in cancer, their expression patterns, and their cellular localization. Most cancer types showed a negative correlation between the gene-set variation analysis (GSVA) scores and infiltration of B cells and neutrophils, and a positive correlation

SUBMITTER: Shen LP 

PROVIDER: S-EPMC10997004 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature