Assessing the causal link between liver function and acute pancreatitis: A Mendelian randomisation study.

ABSTRACT: A correlation has been reported to exist between exposure factors (e.g. liver function) and acute pancreatitis. However, the specific causal relationship remains unclear. This study aimed to infer the causal relationship between liver function and acute pancreatitis using the Mendelian randomisation method. We employed summary data from a genome-wide association study involving individuals of European ancestry from the UK Biobank and FinnGen. Single-nucleotide polymorphisms (SCNPs), closely associated with liver function, served as instrumental variables. We used five regression models for causality assessment: MR-Egger regression, the random-effect inverse variance weighting method (IVW), the weighted median method (WME), the weighted model, and the simple model. We assessed the heterogen

SUBMITTER: Zhang C 

PROVIDER: S-EPMC10997074 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature