Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study.

ABSTRACT:

Background

According to epidemiological studies, particulate matter 2.5 (PM2.5) is a significant contributor to cardiovascular disease (CVD). However, making causal inferences is difficult due to the methodological constraints of observational studies. In this study, we used two-sample Mendelian randomization (MR) to examine the causal relationship between PM 2.5 and the risk of CVD.

Methods

Genome-wide association study (GWAS) statistics for PM2.5 and CVD were collected from the FinnGen and UK Biobanks. Mendelian randomization analyses were applied to explore the causal effects of PM2.5 on CVD by selecting single-nucleotide polymorphisms(SNP) as instrumental variables.

Results

The results revealed that a causal effect was observed between PM2.5 and coronary artery di

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10997086 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature