Hypothermia effects on neuronal plasticity post spinal cord injury.

ABSTRACT:

Background

SCI is a time-sensitive debilitating neurological condition without treatment options. Although the central nervous system is not programmed for effective endogenous repairs or regeneration, neuroplasticity partially compensates for the dysfunction consequences of SCI.

Objective and hypothesis

The purpose of our study is to investigate whether early induction of hypothermia impacts neuronal tissue compensatory mechanisms. Our hypothesis is that although neuroplasticity happens within the neuropathways, both above (forelimbs) and below (hindlimbs) the site of spinal cord injury (SCI), hypothermia further influences the upper limbs' SSEP signals, even when the SCI is mid-thoracic.

Study design

A total of 30 male and female adult rats are randomly assigned to

SUBMITTER: Al-Nashash H 

PROVIDER: S-EPMC10997101 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature