Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner.

ABSTRACT:

Objective

Quantitative values derived from PET brain images are of high interest for neuroscientific applications. Insufficient DT correction (DTC) can lead to a systematic bias of the output parameters obtained by a detailed analysis of the time activity curves (TACs). The DTC method currently used for the Siemens 3T MR BrainPET insert is global, i.e., differences in DT losses between detector blocks are not considered, leading to inaccurate DTC and, consequently, to inaccurate measurements masked by a bias. However, following careful evaluation with phantom measurements, a new block-pairwise DTC method has demonstrated a higher degree of accuracy compared to the global DTC method.

Approach

Differences between the global and the block-pairwise DTC method were studied in thi

SUBMITTER: Issa ASM 

PROVIDER: S-EPMC10997125 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature