Immune cells in the B-cell lymphoma microenvironment: From basic research to clinical applications.

ABSTRACT:

Abstract

B-cell lymphoma is a group of hematological malignancies characterized by variable genetic and biological features and clinical behaviors. The tumor microenvironment (TME) is a complex network in tumors, which consists of surrounding blood vessels, extracellular matrix, immune and non-immune cells, and signaling molecules. Increasing evidence has shown that the TME, especially immune cells within, is a double-edged sword, acting either as a tumor killer or as a promoter of tumor progression. These pro-tumor activities are driven by subpopulations of immune cells that express typical markers but have unique transcriptional characteristics, making tumor-associated immune cells good targets for human anti-cancer therapy by ablating immunosuppressive cells or enhancing immune-

SUBMITTER: Zhang W 

PROVIDER: S-EPMC10997228 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature