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Ligand and Linkage Isomers of Bis(ethylthiocarbamato) Copper Complexes with Cyclic C₆H₈ Backbone Substituents: Synthesis, Characterization, and Antiproliferation Activity.

ABSTRACT: A series of isomeric bis(alkylthiocarbamate) copper complexes have been synthesized, characterized, and evaluated for antiproliferation activity. The complexes were derived from ligand isomers with 3-methylpentyl (H₂L²) and cyclohexyl (H₂L³) backbone substituents, which each yield a pair of linkage isomers. The thermodynamic products CuL^2a/3a have two imino N and two S donors resulting in three five-member chelate rings (555 isomers). The kinetic isomers CuL^2b/3b have one imino and one hydrazino N donor and two S donors resulting in four-, six-, and five-member rings (465 isomers). The 555 isomers have more accessible Cu^II/I potentials (E_1/2 = -811/-768 mV vs. ferrocenium/ferrocene) and lower energy cha

SUBMITTER: Bajaj K

PROVIDER: S-EPMC10997340 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Ligand and Linkage Isomers of Bis(ethylthiocarbamato) Copper Complexes with Cyclic C₆H₈ Backbone Substituents: Synthesis, Characterization, and Antiproliferation Activity.

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Ligand and Linkage Isomers of Bis(ethylthiocarbamato) Copper Complexes with Cyclic C6H8 Backbone Substituents: Synthesis, Characterization, and Antiproliferation Activity.

OmicsDI is part of the ELIXIR infrastructure

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Ligand and Linkage Isomers of Bis(ethylthiocarbamato) Copper Complexes with Cyclic C₆H₈ Backbone Substituents: Synthesis, Characterization, and Antiproliferation Activity.