PFAS alters placental arterial vasculature in term human placentae: A prospective pregnancy cohort study.

ABSTRACT:

Introduction

Perfluoroalkyl substances (PFAS) are synthetic chemicals used in industrial and consumer goods that are widely detected in human populations and are associated with adverse health outcomes, including perinatal health risks and child health. One mechanism of influence may be the impact of PFAS exposure on placental structure and function.

Objectives

The objective of this study is to investigate the relationship between maternal prenatal exposure to PFAS and measures of placental vascularization, and to assess whether changes in vascularization play a role in mediating the impact of PFAS on birth outcomes.

Methods

Using data from a prospective cohort study, we examined associations between second trimester PFAS (individually and as mixtures using Bayesian k

SUBMITTER: Chowdhury SF 

PROVIDER: S-EPMC10997442 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature