Evaluating the biodistribution for [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]F-PSMA-1007 PET/CT with an inter- and intrapatient based analysis.

ABSTRACT:

Background

Liver uptake in [⁶⁸Ga]Ga-PSMA-11 PET is used as an internal reference in addition to clinical parameters to select patients for [¹⁷⁷Lu]Lu-PSMA-617 radioligand therapy (RLT). Due to increased demand, [⁶⁸Ga]Ga-PSMA-11 was replaced by [¹⁸F]F-PSMA-1007, a more lipophilic tracer with different biodistribution and splenic uptake was suggested as a new internal reference. We compared the intra-patient tracer distribution between [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]F-PSMA-1007.

Methods

Fifty patients who underwent PET examinations in two centers with both [¹⁸F]F-PSMA-1007 and [⁶⁸Ga]Ga-PSMA-11 within one year were included. Mean standardized uptake values (SUV_mean) were obtained for li

SUBMITTER: Popescu CE 

PROVIDER: S-EPMC10997563 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature