Physical training attenuates systemic cytokine response and tissue damage triggered by apical periodontitis.

ABSTRACT: Apical periodontitis (AP) is a condition characterized by inflammatory and infectious components in the tooth canal. AP affects periradicular tissues and has systemic repercussions. Physical exercise is a structured activity that requires cardiorespiratory function, and can modulate the inflammatory profile in pathological conditions. As a result, this study aimed to determine the effects of aerobic physical training (PT) on the alveolar bone with and without AP, and its systemic inflammatory repercussions. AP was induced in the mandibular first molars, and PT was performed on a treadmill for five consecutive days over four weeks, with progressive increases in speed and activity time. Blood samples were collected to determine serum cytokine levels using immunoassays, and alveolar bone samp

SUBMITTER: Ferreira RO 

PROVIDER: S-EPMC10997662 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature