Multi-modal Neuroimaging Phenotyping of Mnemonic Anosognosia in the Aging Brain.

ABSTRACT:

Background

Unawareness is a behavioral condition characterized by a lack of self-awareness of objective memory decline. In the context of Alzheimer's Disease (AD), unawareness may develop in predementia stages and contributes to disease severity and progression. Here, we use in-vivo multi-modal neuroimaging to profile the brain phenotype of individuals presenting altered self-awareness of memory during aging.

Methods

Amyloid- and tau-PET (N = 335) and resting-state functional MRI (N = 713) imaging data of individuals from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4)/Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) Study were used in this research. We applied whole-brain voxel-wise and region-of-interest analyses to characterize the

SUBMITTER: Bueicheku E 

PROVIDER: S-EPMC10997795 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature