Apoptotic vesicles are required to repair DNA damage and suppress premature cellular senescence.

ABSTRACT: It is well known that DNA damage can cause apoptosis. However, whether apoptosis and its metabolites contribute to DNA repair is largely unknown. In this study, we found that apoptosis-deficient Fas^mut and Bim^{- /-} mice show significantly elevated DNA damage and premature cellular senescence, along with a significantly reduced number of 16,000 g apoptotic vesicles (apoVs). Intravenous infusion of mesenchymal stromal cell (MSC)-derived 16,000 g apoVs rescued the DNA damage and premature senescence in Fas^mut and Bim^-/- mice. Moreover, a sublethal dose of radiation exposure caused more severe DNA damage, reduced survival rate, and loss of body weight in Fas^mut mice than in wild-type mice, which can be recovered by the infusion o

SUBMITTER: Huang Z 

PROVIDER: S-EPMC10997816 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature