Gut microbiome signature and nasal lavage inflammatory markers in young people with asthma.

ABSTRACT:

Background

Asthma is a complex disease and a severe global public health problem resulting from interactions between genetic background and environmental exposures. It has been suggested that gut microbiota may be related to asthma development; however, such relationships needs further investigation.

Objective

This study aimed to characterize the gut microbiota as well as the nasal lavage cytokine profile of asthmatic and nonasthmatic individuals.

Methods

Stool and nasal lavage samples were collected from 29 children and adolescents with type 2 asthma and 28 children without asthma in Brazil. Amplicon sequencing of the stool bacterial V4 region of the 16S rRNA gene was performed using Illumina MiSeq. Microbiota analysis was performed by QIIME 2 and PICRUSt2. Type 2 as

SUBMITTER: Sampaio Dotto Fiuza B 

PROVIDER: S-EPMC10998106 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature