Premastectomy Radiotherapy and Immediate Breast Reconstruction: A Randomized Clinical Trial.

ABSTRACT:

Importance

Premastectomy radiotherapy (PreMRT) is a new treatment sequence to avoid the adverse effects of radiotherapy on the final breast reconstruction while achieving the benefits of immediate breast reconstruction (IMBR).

Objective

To evaluate outcomes among patients who received PreMRT and regional nodal irradiation (RNI) followed by mastectomy and IMBR.

Design, setting, and participants

This was a phase 2 single-center randomized clinical trial conducted between August 3, 2018, and August 2, 2022, evaluating the feasibility and safety of PreMRT and RNI (including internal mammary lymph nodes). Patients with cT0-T3, N0-N3b breast cancer and a recommendation for radiotherapy were eligible.

Intervention

This trial evaluated outcomes after PreMRT followed by

SUBMITTER: Schaverien MV 

PROVIDER: S-EPMC10998161 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature