Associations between low-moderate prenatal alcohol exposure and brain development in childhood.

ABSTRACT:

Background

The effects of low-moderate prenatal alcohol exposure (PAE) on brain development have been infrequently studied.

Aim

To compare cortical and white matter structure between children aged 6 to 8 years with low-moderate PAE in trimester 1 only, low-moderate PAE throughout gestation, or no PAE.

Methods

Women reported quantity and frequency of alcohol consumption before and during pregnancy. Magnetic resonance imaging was undertaken for 143 children aged 6 to 8 years with PAE during trimester 1 only (n = 44), PAE throughout gestation (n = 58), and no PAE (n = 41). T₁-weighted images were processed using FreeSurfer, obtaining brain volume, area, and thickness of 34 cortical regions per hemisphere. Fibre density (FD), fibre cross-section (FC) and fibre

SUBMITTER: Thompson DK 

PROVIDER: S-EPMC10998198 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature