[18]F-fluoroethyl-l-tyrosine positron emission tomography for radiotherapy target delineation: Results from a Radiation Oncology credentialing program.

ABSTRACT:

Background and purpose

The [18]F-fluoroethyl-l-tyrosine (FET) PET in Glioblastoma (FIG) study is an Australian prospective, multi-centre trial evaluating FET PET for newly diagnosed glioblastoma management. The Radiation Oncology credentialing program aimed to assess the feasibility in Radiation Oncologist (RO) derivation of standard-of-care target volumes (TV_MR) and hybrid target volumes (TV_MR+FET) incorporating pre-defined FET PET biological tumour volumes (BTVs).

Materials and methods

Central review and analysis of TV_MR and TV_MR+FET was undertaken across three benchmarking cases. BTVs were pre-defined by a sole nuclear medicine expert. Intraclass correlation coefficient (ICC) confidence intervals (CIs) evaluated volume agreement

SUBMITTER: Barry N 

PROVIDER: S-EPMC10998205 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature