Expression of KCNN4 in adult-type diffuse gliomas and its correlations with clinicopathological features and patient prognosis.

ABSTRACT:

Background

The KCa3.1 channel (KCNN4) is extensively investigated as an oncogene in human cancers. The current study aimed to explore the clinicopathological significance of KCNN4 expression in patients with primary adult-type diffuse gliomas.

Methods

Demographic, RNA-seq, and follow-up data of 477 patients were retrospectively reviewed. Patients were divided into the experimental and validation groups (278 and 199). KCNN4-related genes were determined by Pearson correlation analysis, and enrichment analyses and tumor-infiltrating immune cell assessments were applied to explore the potential mechanisms of KCNN4 involving glioma progression. The Kaplan-Meier method and the Cox regression analysis were used to evaluate the prognostic value of KCNN4 expression.

Results

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SUBMITTER: Yang J 

PROVIDER: S-EPMC10998241 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature