Use of non-small cell lung cancer multicellular tumor spheroids to study the impact of chemotherapy.

ABSTRACT:

Background

Lung cancers represent the main cause of cancer related-death worldwide. Recently, immunotherapy alone or in combination with chemotherapy has deeply impacted the therapeutic care leading to an improved overall survival. However, relapse will finally occur, with no efficient second line treatment so far. New therapies development based on the comprehension of resistance mechanisms is necessary. However, the difficulties to obtain tumor samples before and after first line treatment hamper to clearly understand the consequence of these molecules on tumor cells and also to identify adapted second line therapies.

Methods

To overcome this difficulty, we developed multicellular tumor spheroids (MCTS) using characterized Non-Small Cell Lung Cancer (NSCLC) cell lines, mon

SUBMITTER: Hulo P 

PROVIDER: S-EPMC10998296 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature