The relationship between serum astroglial and neuronal markers and AQP4 and MOG autoantibodies.

ABSTRACT:

Background

Certain demyelinating disorders, such as neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) exhibit serum autoantibodies against aquaporin-4 (αAQP4) and myelin oligodendrocyte glycoprotein (αMOG). The variability of the autoantibody presentation warrants further research into subtyping each case.

Methods

To elucidate the relationship between astroglial and neuronal protein concentrations in the peripheral circulation with occurrence of these autoantibodies, 86 serum samples were analyzed using immunoassays. The protein concentration of glial fibrillary acidic protein (GFAP), neurofilament light chain (NFL) and tau protein was measured in 3 groups of subcategories of suspected NMOSD: αAQP4 posi

SUBMITTER: Chatanaka MK 

PROVIDER: S-EPMC10998414 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature