Ontology highlight
ABSTRACT:
SUBMITTER: Pires L
PROVIDER: S-EPMC10998568 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Pires Layla L Khattak Shireen S Pratavieira Sebastiao S Calcada Carla C Romano Renan R Yucel Yeni Y Bagnato Vanderlei S VS Kurachi Cristina C Wilson Brian C BC
Proceedings of the National Academy of Sciences of the United States of America 20240329 14
Photodynamic therapy (PDT) relies on a series of photophysical and photochemical reactions leading to cell death. While effective for various cancers, PDT has been less successful in treating pigmented melanoma due to high light absorption by melanin. Here, this limitation is addressed by 2-photon excitation of the photosensitizer (2p-PDT) using ~100 fs pulses of near-infrared laser light. A critical role of melanin in enabling rather than hindering 2p-PDT is elucidated using pigmented and non-p ...[more]