Phosphocholine-induced energy source shift alleviates mitochondrial dysfunction in lung cells caused by geospecific PM_2.5 components.

ABSTRACT: Fine particulate matter (PM_2.5) is globally recognized for its adverse implications on human health. Yet, remain limited the individual contribution of particular PM_2.5 components to its toxicity, especially considering regional disparities. Moreover, prevention solutions for PM_2.5-associated health effects are scarce. In the present study, we comprehensively characterized and compared the primary PM_2.5 constituents and their altered metabolites from two locations: Taiyuan and Guangzhou. Analysis of year-long PM_2.5 samples revealed 84 major components, encompassing organic carbon, elemental carbon, ions, metals, and organic chemicals. PM_2.5 from Taiyuan exhibited higher contamination, associated health risks, dithiothreitol

SUBMITTER: Song Y 

PROVIDER: S-EPMC10998597 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature