Molecular mechanism of the metal-independent production of hydroxyl radicals by thiourea dioxide and H₂O₂.

ABSTRACT: It is well-known that highly reactive hydroxyl radicals (HO^•) can be produced by the classic Fenton system and our recently discovered haloquinone/H₂O₂ system, but rarely from thiol-derivatives. Here, we found, unexpectedly, that HO^• can be generated from H₂O₂ and thiourea dioxide (TUO₂), a widely used and environmentally friendly bleaching agent. A carbon-centered radical and sulfite were detected and identified as the transient intermediates, and urea and sulfate as the final products, with the complementary application of electron spin-trapping, oxygen-18 isotope labeling coupled with HPLC/MS analysis. Density functional theory calculations were conducted to further elucidate the detailed pathways for HO^•<

SUBMITTER: Mao L 

PROVIDER: S-EPMC10998598 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature