Bovine neutrophils kill the sexually-transmitted parasite Tritrichomonas foetus using trogocytosis.

ABSTRACT: The protozoan parasite Tritrichomonas foetus (T. foetus) is the causative organism of bovine trichomonosis (also referred to as trichomoniasis), a sexually-transmitted infection that reduces fertility in cattle. Efforts to control trichomonosis on cattle farms are hindered by the discouragement of antibiotic use in agriculture, and the incomplete, short-lived protection conferred by the current vaccines. A more complete mechanistic understanding of what effective immunity to T. foetus entails could enable the development of more robust infection control strategies. While neutrophils, the primary responders to infection, are present in infected tissues and have been shown to kill the parasite in vitro, the mechanism they use for parasite killing has not been established. Here, we show that

SUBMITTER: Najera J 

PROVIDER: S-EPMC10998815 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature