Genomics reveals heterogeneous Plasmodium falciparum transmission and selection signals in Zambia.

ABSTRACT:

Background

Genomic surveillance is crucial for monitoring malaria transmission and understanding parasite adaptation to interventions. Zambia lacks prior nationwide efforts in malaria genomic surveillance among African countries.

Methods

We conducted genomic surveillance of Plasmodium falciparum parasites from the 2018 Malaria Indicator Survey in Zambia, a nationally representative household survey of children under five years of age. We whole-genome sequenced and analyzed 241 P. falciparum genomes from regions with varying levels of malaria transmission across Zambia and estimated genetic metrics that are informative about transmission intensity, genetic relatedness between parasites, and selection.

Results

We provide genomic evidence of widespread within-host polyge

SUBMITTER: Fola AA 

PROVIDER: S-EPMC10998850 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature