ScButterfly: a versatile single-cell cross-modality translation method via dual-aligned variational autoencoders.

ABSTRACT: Recent advancements for simultaneously profiling multi-omics modalities within individual cells have enabled the interrogation of cellular heterogeneity and molecular hierarchy. However, technical limitations lead to highly noisy multi-modal data and substantial costs. Although computational methods have been proposed to translate single-cell data across modalities, broad applications of the methods still remain impeded by formidable challenges. Here, we propose scButterfly, a versatile single-cell cross-modality translation method based on dual-aligned variational autoencoders and data augmentation schemes. With comprehensive experiments on multiple datasets, we provide compelling evidence of scButterfly's superiority over baseline methods in preserving cellular heterogeneity while transl

SUBMITTER: Cao Y 

PROVIDER: S-EPMC10998864 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature