Ontology highlight
ABSTRACT:
SUBMITTER: Unione L
PROVIDER: S-EPMC10998905 | biostudies-literature | 2024 Apr
REPOSITORIES: biostudies-literature
Unione Luca L Ammerlaan Augustinus N A ANA Bosman Gerlof P GP Uslu Elif E Liang Ruonan R Broszeit Frederik F van der Woude Roosmarijn R Liu Yanyan Y Ma Shengzhou S Liu Lin L Gómez-Redondo Marcos M Bermejo Iris A IA Valverde Pablo P Diercks Tammo T Ardá Ana A de Vries Robert P RP Boons Geert-Jan GJ
Nature communications 20240406 1
Prototypic receptors for human influenza viruses are N-glycans carrying α2,6-linked sialosides. Due to immune pressure, A/H3N2 influenza viruses have emerged with altered receptor specificities that bind α2,6-linked sialosides presented on extended N-acetyl-lactosamine (LacNAc) chains. Here, binding modes of such drifted hemagglutinin's (HAs) are examined by chemoenzymatic synthesis of N-glycans having <sup>13</sup>C-labeled monosaccharides at strategic positions. The labeled glycans are employe ...[more]