Extracellular vesicle encapsulated Homer1a as novel nanotherapeutics against intracerebral hemorrhage in a mouse model.

ABSTRACT: Homer1a and A2 astrocytes are involved in the regulation of inflammation induced by intracerebral hemorrhage (ICH). However, there is no anticipated treatment strategy based on the anti-inflammatory effect of Homer1a and A2 astrocytes. Here, we successfully induced A2 astrocytes in vitro, and then we report an efficient method to prepare Homer1a⁺ EVs derived from A2 astrocytes which making it more stable, safe, and targetable to injured neurons. Homer1a⁺ EVs promotes the conversion of A1 to A2 astrocytes in ICH mice. Homer1a⁺ EVs inhibits activation and nuclear translocation of NF-κB, thereby regulating transcription of IL-17A in neurons. Homer1a⁺ EVs inhibits the RAGE/NF-κB/IL-17 signaling pathway and the binding ability of IL-17A: IL17-AR and R

SUBMITTER: Fei X 

PROVIDER: S-EPMC10999083 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature