The circadian metabolome of atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by dry, pruritic skin. Several studies have described nocturnal increases in itching behavior, suggesting a role for the circadian rhythm in modulating symptom severity. However, the circadian rhythm of metabolites in the skin and serum of patients with AD is yet to be described.

Objective

We sought to assess circadian patterns of skin and serum metabolism in patients with AD.

Methods

Twelve patients with moderate to severe AD and 5 healthy volunteers were monitored for 28 hours in a controlled environment. Serum was collected every 2 hours and tape strips every 4 hours from both lesional and nonlesional skin in participants with AD and location-, sex-, and age-matched healthy skin

SUBMITTER: Ratley G 

PROVIDER: S-EPMC10999347 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature