Effects of occupational exposure to metal fume PM_2.5 on lung function and biomarkers among shipyard workers: a 3-year prospective cohort study.

ABSTRACT:

Objective

This study investigates the associations of α1-antitrypsin, inter-α-trypsin inhibitor heavy chain (ITIH4), and 8-isoprostane with lung function in shipyard workers exposed to occupational metal fume fine particulate matter (PM_2.5), which is known to be associated with adverse respiratory outcomes.

Methods

A 3-year follow-up study was conducted on 180 shipyard workers with 262 measurements. Personal exposure to welding fume PM_2.5 was collected for an 8-h working day. Pre-exposure, post-exposure, and delta (∆) levels of α1-antitrypsin, ITIH4, and 8-isoprostane were determined in urine using enzyme-linked immunosorbent assays. Post-exposure urinary metals were sampled at the beginning of the next working day and analyzed by inductively coupled pl

SUBMITTER: Tran HM 

PROVIDER: S-EPMC10999385 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature