Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study.

ABSTRACT:

Background

Allergic conjunctivitis (AC) afflicts a significant portion of the global populace. Yet, its metabolic foundations remain largely unexplored.

Methods

We applied Mendelian Randomization (MR) and Linkage Disequilibrium Score Regression (LDSC) to scrutinize a cohort comprising 20 958 AC cases and 356 319 controls. Data were amalgamated from the metabolomics GWAS server and the FinnGen project, under strict quality control protocols.

Results

Using two-sample MR analysis, 486 blood metabolites were investigated in relation to AC. The IVW approach highlighted 18 metabolites as closely tied to AC risk; of these, 16 retained significance post sensitivity assessments for heterogeneity and horizontal pleiotropy. LDSC analysis, adopted to bolster our findings and nega

SUBMITTER: Zou X 

PROVIDER: S-EPMC10999487 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature