Profiling of differentially expressed MicroRNAs in familial hypercholesterolemia via direct hybridization.

ABSTRACT:

Background

Individuals with homozygous familial hypercholesterolemia (HoFH) have a severe clinical problem in their first decade of life, which is not usually present in heterozygous FH (HeFH) individuals. For this latter group of patients, FH diagnosis is mostly severely delayed with a significant increase in the risk of angina, myocardial infarction, peripheral artery disease, stroke, and cardiovascular and all-cause mortality.

Methods

This study used various bioinformatics tools to analyze microarray data and identify critical miRNAs and their target genes associated with FH and its severity. Differentially expressed serum miRNAs from direct hybridization microarray data in three groups of subjects: healthy, HeFH, and HoFH. The differential expressed miRNAs were determine

SUBMITTER: Cione E 

PROVIDER: S-EPMC10999490 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature