Cerclage prevents ascending intrauterine infection in pregnant mice.

ABSTRACT:

Background

The treatment for cervical insufficiency is cerclage surgery. Although cerclage is a common therapy for prevention of preterm birth, there is no consensus about its mechanism of efficacy. Previous investigators have hypothesized that cerclage prevents preterm birth by improving the cervical barrier to ascending infection. However, this hypothesis is difficult to study in human pregnancy.

Objective

In a mouse model of ascending infection, we hypothesized that a cerclage improves the cervical barrier leading to decreased ascending intrauterine infection and inflammation. An abdominal cerclage was studied because a vaginal cerclage is not feasible in mice.

Study design

To perform an abdominal cerclage, laparotomy was performed on timed, pregnant C57BL/6 mice o

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10999506 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature