GWAS of Folate Metabolism With Gene-environment Interaction Analysis Revealed the Possible Role of Lifestyles in the Control of Blood Folate Metabolites in Japanese: The J-MICC Study.

ABSTRACT:

Background

The present genome-wide association study (GWAS) aimed to reveal the genetic loci associated with folate metabolites, as well as to detect related gene-environment interactions in Japanese.

Methods

We conducted the GWAS of plasma homocysteine (Hcy), folic acid (FA), and vitamin B₁₂ (VB₁₂) levels in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study participants who joined from 2005 to 2012, and also estimated gene-environment interactions. In the replication phase, we used data from the Yakumo Study conducted in 2009. In the discovery phase, data of 2,263 participants from four independent study sites of the J-MICC Study were analyzed. In the replication phase, data of 573 participants from the Yakumo Study were analyzed.

Re

SUBMITTER: Tsukamoto M 

PROVIDER: S-EPMC10999522 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature