Spontaneous brain activity in the hippocampal regions could characterize cognitive impairment in patients with Parkinson's disease.

ABSTRACT:

Objective

This study aimed to investigate whether spontaneous brain activity can be used as a prospective indicator to identify cognitive impairment in patients with Parkinson's disease (PD).

Methods

Resting-state functional magnetic resonance imaging (RS-fMRI) was performed on PD patients. The cognitive level of patients was assessed by the Montreal Cognitive Assessment (MoCA) scale. The fractional amplitude of low-frequency fluctuation (fALFF) was applied to measure the strength of spontaneous brain activity. Correlation analysis and between-group comparisons of fMRI data were conducted using Rest 1.8. By overlaying cognitively characterized brain regions and defining regions of interest (ROIs) based on their spatial distribution for subsequent cognitive stratification stu

SUBMITTER: Chen P 

PROVIDER: S-EPMC10999557 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature