Polygenic risk associated with Alzheimer's disease and other traits influences genes involved in T cell signaling and activation.

ABSTRACT:

Introduction

T cells, known for their ability to respond to an enormous variety of pathogens and other insults, are increasingly recognized as important mediators of pathology in neurodegeneration and other diseases. T cell gene expression phenotypes can be regulated by disease-associated genetic variants. Many complex diseases are better represented by polygenic risk than by individual variants.

Methods

We first compute a polygenic risk score (PRS) for Alzheimer's disease (AD) using genomic sequencing data from a cohort of Alzheimer's disease (AD) patients and age-matched controls, and validate the AD PRS against clinical metrics in our cohort. We then calculate the PRS for several autoimmune disease, neurological disorder, and immune function traits, and correlate these PR

SUBMITTER: Dressman D 

PROVIDER: S-EPMC10999606 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature