Gut microbiota and risk of coronary heart disease: a two-sample Mendelian randomization study.

ABSTRACT:

Background

The relationship between gut microbiota composition and coronary heart disease (CHD) has been recently reported in several observational studies. However, the causal effect of gut microbiota on coronary heart disease is uncharted.

Objective

This study attempted to investigate the effect of gut microbiota on coronary heart disease by Mendelian randomization (MR) analysis.

Methods

Through the two-sample MR method, single-nucleotide polymorphisms relevant to gut microbiota were selected as instrument variables to evaluate the causal association between gut microbiota and the risk of CHD.

Results

According to the selection criteria of the inverse variance-weighted average method, Class Actinobacteria, Class Lentisphaeria, Family Clostridiales vadinBB60gr

SUBMITTER: Hu XZ 

PROVIDER: S-EPMC10999620 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature