Estimating the effect of realistic improvements of metformin adherence on COVID-19 mortality using targeted machine learning.

ABSTRACT:

Background

Type 2 diabetes elevates the risk of severe outcomes in COVID-19 patients, with multiple studies reporting higher case fatality rates. Metformin is a widely used medication for glycemic management. We hypothesize that improved adherence to metformin may lower COVID-19 post-infection mortality risk in this group. Utilizing data from the Mexican Social Security Institute (IMSS), we investigate the relationship between metformin adherence and mortality following COVID-19 infection in patients with chronic metformin prescriptions.

Methods

This is a retrospective cohort study consisting of 61,180 IMSS beneficiaries who received a positive polymerase chain reaction (PCR) or rapid test for SARS-CoV-2 and had at least two consecutive months of metformin prescriptions prio

SUBMITTER: Qiu S 

PROVIDER: S-EPMC10999684 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature