Generation of contractile forces by three-dimensional bundled axonal tracts in micro-tissue engineered neural networks.

ABSTRACT: Axonal extension and retraction are ongoing processes that occur throughout all developmental stages of an organism. The ability of axons to produce mechanical forces internally and respond to externally generated forces is crucial for nervous system development, maintenance, and plasticity. Such axonal mechanobiological phenomena have typically been evaluated in vitro at a single-cell level, but these mechanisms have not been studied when axons are present in a bundled three-dimensional (3D) form like in native tissue. In an attempt to emulate native cortico-cortical interactions under in vitro conditions, we present our approach to utilize previously described micro-tissue engineered neural networks (micro-TENNs). Here, micro-TENNs were comprised of discrete populations of

SUBMITTER: Chouhan D 

PROVIDER: S-EPMC10999686 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature