Genetically predicted causal effects of gut microbiota on spinal pain: a two-sample Mendelian randomization analysis.

ABSTRACT:

Background

Observational studies have hinted at a correlation between the gut microbiota and spinal pain (SP). However, the impact of the gut microbiota on SP remains inconclusive.

Methods

In this study, we employed a two-sample Mendelian randomization (MR) analysis to explore the causal relationship between the gut microbiota and SP, encompassing neck pain (NP), thoracic spine pain (TSP), low back pain (LBP), and back pain (BP). The compiled gut microbiota data originated from a genome-wide association study (GWAS) conducted by the MiBioGen consortium (n = 18,340). Summary data for NP were sourced from the UK Biobank, TSP from the FinnGen Biobank, and LBP from both the UK Biobank and FinnGen Biobank. Summary data for BP were obtained from the UK Biobank. The primary

SUBMITTER: Hong S 

PROVIDER: S-EPMC10999687 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature