Genomic insights into local-scale evolution of ocular <i>Chlamydia trachomatis</i> strains within and between individuals in Gambian trachoma-endemic villages.

ABSTRACT: Trachoma, a neglected tropical disease caused by Chlamydia trachomatis (Ct) serovars A-C, is the leading infectious cause of blindness worldwide. Africa bears the highest burden, accounting for over 86 % of global trachoma cases. We investigated Ct serovar A (SvA) and B (SvB) whole genome sequences prior to the induction of mass antibiotic drug administration in The Gambia. Here, we explore the factors contributing to Ct strain diversification and the implications for Ct evolution within the context of ocular infection. A cohort study in 2002-2003 collected ocular swabs across nine Gambian villages during a 6 month follow-up study. To explore the genetic diversity of Ct within and between individuals, we conducted whole-genome sequencing (WGS) on a limited number (n=43) of Ct

SUBMITTER: Ghasemian E 

PROVIDER: S-EPMC10999739 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature