Strain background of Candida albicans interacts with SIR2 to alter phenotypic switching.

ABSTRACT: The genetic background between strains of a single species and within a single strain lineage can significantly impact the expression of biological traits. This genetic variation may also reshape epigenetic mechanisms of cell identity and environmental responses that are controlled by interconnected transcriptional networks and chromatin-modifying enzymes. Histone deacetylases, including sirtuins, are critical regulators of chromatin state and have been directly implicated in governing the phenotypic transition between the 'sterile' white state and the mating-competent opaque state in Candida albicans, a common fungal commensal and pathogen of humans. Here, we found that a previously ambiguous role for the sirtuin SIR2 in C. albicans phenotypic switching is likely link

SUBMITTER: Woodruff AL 

PROVIDER: S-EPMC10999749 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature