Increased prevalence of CFTR variants and susceptibility to CRS: A real-world study based on Chinese children.

ABSTRACT:

Background

Chronic Rhinosinusitis is a common disease in children. The main function of CFTR is to maintain the thickness of the mucous layer on the surface of the nasal mucosa. CFTR disease-causing variant can cause CFTR protein dysfunction and induce or aggravate chronic infection. However, the carrying status of the CFTR variants in the Chinese population is not clear.

Objective

To study the frequency and variants of CFTR in Chinese children with CRS and to analyze the CFTR variants and the clinical characteristics and susceptibility to CRS.

Methods

Whole Exome Sequencing was performed to analyze the CFTR genes in a total of 106 CRS children from the Chinese mainland area. The CFTR variants, frequency and clinical data were

SUBMITTER: Han Y 

PROVIDER: S-EPMC10999871 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature