Evolution of the enhancer-rich regulatory region of the gene for the cell-type specific transcription factor POU1F1.

ABSTRACT: Precise spatio-temporal expression of genes in organogenesis is regulated by the coordinated interplay of DNA elements such as promoter and enhancers present in the regulatory region of a given locus. POU1F1 transcription factor plays a crucial role in the development of somatotrophs, lactotrophs and thyrotrophs in the anterior pituitary gland, and in maintaining high expression of growth hormone, prolactin and TSH. In mouse, expression of POU1F1 is controlled by a region fenced by two CTCF sites, containing 5 upstream enhancer elements, designated E-A (5' to 3'). Elements C, B and A correspond to elements shown previously to play a role in pituitary development and hormonal expression; functional roles for elements E and D have not been reported. We performed comparative sequence a

SUBMITTER: Wallis M 

PROVIDER: S-EPMC10999999 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature