Widespread S-persulfidation in activated macrophages as a protective mechanism against oxidative-inflammatory stress.

ABSTRACT: Acute inflammatory responses often involve the production of reactive oxygen and nitrogen species by innate immune cells, particularly macrophages. How activated macrophages protect themselves in the face of oxidative-inflammatory stress remains a long-standing question. Recent evidence implicates reactive sulfur species (RSS) in inflammatory responses; however, how endogenous RSS affect macrophage function and response to oxidative and inflammatory insults remains poorly understood. In this study, we investigated the endogenous pathways of RSS biogenesis and clearance in macrophages, with a particular focus on exploring how hydrogen sulfide (H₂S)-mediated S-persulfidation influences macrophage responses to oxidative-inflammatory stress. We show that classical activation of mous

SUBMITTER: Salti T 

PROVIDER: S-EPMC11000178 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature